Hepatic Dose : No dose adjustment recommended. Dose as in normal renal functionĭialysed.

Renal Dose : Dose in Renal Impairment GFR (mL/min)ĭose in Patients undergoing Renal Replacement Therapies No significant interactions are known other than antagonism of coumarin anticoagulants. Neonates: In infants (particularly premature babies), excessive doses of vitamin K analogs during the first few days of life may cause hyperbilirubinemia this in turn may result in severe hemolytic anemia, hemoglobinuria, kernicterus, leading to brain damage or even death. If you are giving this medication to yourself at home, learn all preparation and usage. Large doses of vitamin K or its analogues may further depress liver function in patients with severe hepatic disease and thereby further decrease the concentration of prothrombin. Dosage is based on your medical condition and response to treatment. Pain, swelling, and tenderness at the injection site may occur. Bronchospasm, shock, cardiac and/or respiratory arrest may also occur. 13: Apixaban (Eliquis) dosing for treatment of VTE and prevention of recurrent.

Transient flushing sensations and peculiar sensations of taste have been observed following phytonadione injection as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea, and cyanosis. Non-Vitamin K Antagonist Oral Anticoagulants (NOAC) Guidelines. Alternatively, 10 mg IV, IM or subcutaneously may be administered.

Vitamin k antidote dose